教授

基本信息

       方铭，男，博士生导师，闽江学者特聘教授，担任国家海水鱼产业技术体系大黄鱼种质资源与品种改良岗位科学家，入选福建省百千万人才工程计划、福建省高层次人才B类，入选第十批厦门市双百计划。福建水产学会理事，福建遗传学会理事，福建生物信息学会理事。

联系方式：Email: fangming618@126.com

通讯地址：厦门市集美区印斗路43号，集美大学水产学院（361021）

主要研究方向

水产生物遗传育种学。

       1. 水产经济动植物种质特性评价和遗传改良技术研究；

       2. 水产养殖动物的数量遗传学、生物信息学、基因组学和分子遗传学。

科研项目

1. 大黄鱼速生抗锥体虫病复合性状新种质创制，FJHYF-L-2025-3，197万元，2025-2026，负责人。2025年度福建省促进海洋与渔业产业高质量发展专项资金项目。

2. 大黄鱼种质资源和品种改良岗位，国家海水鱼产业技术体系（CARS-47-G04），2024-2025，140万元，主持。

3. 国家科技部重大专项：大黄鱼种质遗传评价及育种共性技术研究，2022YFD2401001，2022-2027，130万，在研，子课题负责人。

4. 国家科技部重大专项：蓝色粮仓重大专项重要养殖鱼类优良种质创制与生殖操作技术研究子课题，2018YFD0901201，2018/12-2022/12，115万，在研，子课题负责人。

5. 国家自然科学基金面上项目，基于混池测序技术的黄姑鱼红头病抗病位点超精细定位，31872560，2019/01-2022/12，62万，结题，主持

6. 福建省种业创新与产业化工程项目大黄鱼新品种选育，2021FJSCZY01,2022/01-2026/12，110万，在研，主持。

7. 闽江学者支持经费：大黄鱼高不饱和脂肪酸（HUFA）的遗传解析，2019.7-2024.7，200万，在研，主持。

8. 国家自然科学基金面上项目，利用高通量测序数据检测顺式作用遗传变异的新方法及其应用，31672399，2017/01-2020/12，64万，结题，主持

9. 福建省自然科学基金重点项目，影响大黄鱼生长差异的主效基因及功能突变鉴定，2021J02045，2022/01-2025/12，30万，在研，主持

主要成果

1. Gu LL, Wu HS, Liu TY, Zhang YJ, He JC, Liu XL, Wang ZY, Chen GB*, Jiang D*, Fang M*.. Rapid and accurate multi-phenotype imputation for millions of individuals. Nature Communications. 2025 Jan 4;16(1):387.

2. Jing Wen, Cun Yin, Shisheng Wang, Dan Jiang, Zhiyong Wang*, Ming Fang*,The effect of the si gene on glucose adaptation ability in fish,Aquaculture,2026,610,742897.

3. Cun Yin#, Shiwei zhang#, Jing Wen, Shisheng Wang, Tianyu Xie, Zhengde Chen, Zhiyong Wang, Dan Jiang*, Ming Fang*,CRISPR/Cas9-mediated ehd3 knockout enhances high unsaturated fatty acid content in zebrafish muscle,Food Bioscience, 2025,71,107164,

4. Hailiang Huang#, Ming Fang#, Luke Jostins#, Masa U. Mirkov, International the IBD Genetics Consortium, Michel Georges*, Jeffrey C. Barret* and Mark J. Daly*. Fine-mapping inflammatory bowel disease loci to single-variant resolution. Nature，2017,547, 173–178.

5. Meng Zhou, Yingbo Yuan, Yongjie Zhang, Wenjing Zhang, Ruitao Zhou, Jiaojun Ji, Hongshan Wu, Yaning Zhao, Dongling Zhang, Bo Liu, Dan Jiang, Zhiyong Wang, Ming Fang*. The study of the genomic selection of white gill disease resistance in large yellow croaker (Larimichthys crocea). Aquaculture, 2023, 574,15,739682.

6. 顾林林, 王志勇, 方铭*. 一种基于人工智能的基因组选择方法. 集美大学学报（自然科学版）,2023年,第3期,第28卷,205-213（获2024年中国水产学会优秀论文奖）.

7. Wenjing Zhang, Guijia Liu, Linlin Gu, Kun Ye, Dongling Zhang, Dan Jiang, Zhiyong Wang, Ming Fang*, Gene mapping of resistance to red head disease with Pool-seq in the yellow drum, Aquaculture, 2022, 552:737923（5.135/Q1，Top期刊）.

8. Wenjing Zhang, Wanbo Li, Guijia Liu, Linlin Gu, Kun Ye, Yongjie Zhang, Wei Li, Dan Jiang; Zhiyong Wang;* Ming Fang* Evaluation for the effect of low-coverage sequencing on genomic selection in large yellow croaker, Aquaculture, 2020, 534: 736323（IF: 5.135/Q1，Top期刊）.

9. Liu G , Han Z , Jiang D , Li W, Zhang WJ, Ye K, Gu LL, Dong LS, Fang M*, Wang ZY*. Genome-wide association study identifies loci for traits related to swim bladder in yellow drum (Nibea albiflora). Aquaculture, 2020, 526:735327（IF: 5.135/Q1，Top期刊）.

10. Li Zeyu, Fang Ming, Tang Xin, Zhang Dongling, Wang Zhiyong*. Disentangling genetic variation for endurance and resistance to visceral white-nodules disease in large yellow croaker (Larimichthys crocea) using genome information. Aquaculture. 2022(564).739045. 10.1016/j.aquaculture.2022.739045.

11. ZhenXi Zhang, Zhiyong Wang, Ming Fang, Kun Ye , Xin Tang, Dong Ling Zhang*. Genome-wide association analysis on host resistance against the rotten body disease in a naturally infected population of large yellow croaker Larimichthys crocea. Aquaculture. 2022(548),737615

12. Dan Jiang; Wanbo Li; Zhiyong Wang; * Ming Fang* GenomeWide Identification of Cisacting Expression QTLs in Large Yellow Croaker, Marine Biotechnology, 2021,23(2):225-232.

13. Hu Han, Man-Man Yang, Jiang Dan, Sheng-Yu Chao, Xing-Ju Zhang, Qiang Wei, Tao Chen, Qi-Ju Wang, Cheng-Ye Yang, Bater Wulan, Ting-Ting Zhang, Gang Gen, Mengkedala, Bin Li, Wei-Dong Deng, Ze-Pu Miao, Ran Wang, Qing-Feng Zhang, Lin Li, Ming Fang*, Yong Li*, Selection signatures in goats reveal a novel deletion mutant underlying cashmere yield and diameter, GigaScience, Volume 11, 2022, giac107, https://doi.org/10.1093/gigascience/giac107

14. Liu G, Dong L, Gu LL, Han ZF, Zhang WJ, Fang M* & Wang ZY*. Evaluation of Genomic Selection for Seven Economic Traits in Yellow Drum (Nibea albiflora). Marine Biotechnology. 21, 806–812 (2019).

15. Li Y, Li B, Yang M, Han H, Chen T, Wei Q, Miao Z, Yin L, Wang R, Shen J, Li X, Xu X, Fang M* and Zhao S*. Genome-Wide association study and fine mapping reveals Candidate Genes for Birth Weight of Yorkshire and Landrace Pigs. Frontier in Genetics. 2020,11:183.

16. 张波, 姜丹, 张东玲, 王志勇, 方铭*. 大黄鱼生长速度差异个体肌肉组织的转录组比较分析.水产学报.2022.(https://www.cnki.com.cn/Article/CJFDTotal-SCKX20220530000.htm).

17. Jiang, D., Xin, C., Ye, J. Fang M.*. ICGRM: integrative construction of genomic relationship matrix combining multiple genomic regions for big dataset. BMC Bioinformatics, 2019,20, 731.

18. Jun-Feng Gao, Yuan Gao, Jian-Hua Qiu, Qiao-cheng Chang, Yan Zhang, Ming Fang*, Chun-Ren Wang*. De novo assembly and functional annotations of the transcriptome of Metorchis orientalis (trematoda: Opisthorchiidae). Experimental Parasitology,2018,184,90-96.

19. Ming Fang, Michel Georges*, BayesFM: a software program to fine-map multiple causative variants in GWAS identified risk loci. 2016, Biorxiv

20. Changliang Qiu#, Linsong Dong#, Shijun Xiao, Shuangbin Xu, Ming Fang, Zhiyong Wang. Genetic parameters estimation of Nine Quantitative Traits by a marker-based method in Large Yellow Croaker, Larimichthys crocea (Rechardson). 2017,46, 5892-5900. Aquaculture Research.

21. Yuxue Gao, Linsong Dong, shuangbin Xu, Shijun Xiao, Ming Fang, Zhiyong Wang*. Genome-wide association study using single SNP analysis and Bayesian method for swim bladder index and gonadosomatic index in large yellow croaker. Aquaculture,2018(486),26-30.

22. Linsong　Dong; Ming Fang, Zhiyong Wang*. Prediction of genomic breeding values using new computing strategies for the implementation of MixP. Scientific Reports,2017,7,17200.

23. Jun-Feng Gao, Guo-Hua Liu, Hong Duan, Yuan Gao, Yan Zhang, Qiao-Cheng Chang, Ming Fang*, Chun-Ren Wang*. Complete mitochondrial genomes of Triodontophorus serratus and Triodontophorus nipponicus, and their comparison with Triodontophorus brevicauda.. 2017. Experimental Parasitology.