教授

一、基本情况

陈天圣，男，教授、博导。福建省闽江学者特聘教授，集美大学领军人才。于2002年毕业于厦门大学生命科学学院，获理学硕士学位，2008年毕业于新加坡国立大学，获博士学位。迄今为止，主持国家重点基础研究项目课题、国家自然科学基金项目、国家重点基础研究项目子课题、福建省自然科学基金面上项目、福建省种业创新与产业化工程项目、校高层次人才引进项目、学校创新项目等多项，研究结果在Nucleic Acids Res，Proc Natl Acad Sci USA，Endocrinology，Front Genet, Int J Mol Sci, J Transl Med., J Fish Dis等期刊发表SCI论文40余篇，中文期刊论文20余篇。2021年入选福建省高层次人才，2022年入选厦门市引进高层次人才“双百计划”高层次创新人才。

二、教学情况

主讲博士生《水产生物遗传育种前沿》，硕士生和本科生《科技文献检索与写作》，分子生物学《双语》等课程。

三、研究方向

基因编辑系统的优化；鱼类基因功能的解析和在抗病或性控的应用；鳗鲡人工繁育研究。

四、主持的科研项目

1. 2024年，国家重点研究计划项目课题，鳗鲡高质量亲本培育与人工繁殖技术开发；

2. 2024年，福建省自然科学基金面上项目，鳗鲡促卵泡生长激素FSH的表达和功能分析；

3. 2024年，横向项目，重组扩增聚合酶的制备和应用项目；

4. 2023年，集美大学团队国家联合育种攻关计划鳗鲡繁育项目；

5. 2022年，厦门市引进高层次人才“双百计划”高层次创新人才项目；

6. 2023年，国家自然科学基金面上项目，宿主Jun基因突变体抗石斑鱼神经坏死病毒的分子机理(32273127)，；

7. 2021年，福建省海洋与渔业局，鲍鱼种业创新与产业开发（2021FJSCZY02）子课题；

8. 2020年，集美大学高层次人才启动项目，基因编辑在青鳉分子抗病育种的研究ZQ2020003；

9. 2018年，国家自然科学基金面上项目，青鳉母源性pax6b基因调控原生殖细胞迁移的分子机理研究(31771648)；

10. 2016年，国家自然科学基金面上项目第二参与人，中华鲟生殖相关细胞系的建立及对温度应激的机理研究，(31672653)。

五、近年发表的代表性论文

1. Jiangling Li1†, Jingjie Liang1†, Mengyang Wang, Yuewen Jiang, Wen Li, Mingxi Huang, Yan Huang, Yangjie Xie, Jianchun Chen and Tiansheng Chen*. Full‑length transcriptome analysis of male and female gonads in Japanese Eel (Anguilla japonica).  BMC Genomics (2025) 26:89

2. Jingjie Liang †, Yan Huang † , Jiangling Li, Ruoxue Chen, Yanlong Lin, Haiqing Li, Xiangrui Cao and Tiansheng Chen*. 2024. Genomic Analysis and Functional Validation of Bidirectional Promoters in Medaka (Oryzias latipes). Int. J. Mol. Sci. 2024, 25, 13726. https://doi.org/10.3390/ijms252413726

3. Deng, Ju, Yan Huang, Jingjie Liang, Yuewen Jiang, and Tiansheng Chen*. 2024. "Medaka (Oryzias latipes) Dmrt3a Is Involved in Male Fertility" Animals 14, no. 16: 2406. https://doi.org/10.3390/ani14162406

4. Lei Chen,#, Yan Huang,#, Qi-Hua Pan, Meng-Yang Wang, Jing-Jie Liang, Tian-Sheng Chen*. Chinese medaka (Oryzias sinensis) dmrt1 gene converts female to male in medaka (Oryzias latipes). BBA- General Subjects 1868 (2024) 130664; https://doi. org/10.1016/j.bbagen.2024.130664.

5. Yuewen JIANG1, Qihua PAN2, Zhi WANG1, Ke LU1, Bilin XIA1, Tiansheng CHEN*. Efficient genome editing in Medaka (Oryzias latipes) using a codon optimized SaCas9 system. J Zhejiang Univ-Sci B (Biomed & Biotechnol). 2024 12（25）; https://doi.org/10.1631/jzus.B2300899

6. Ronggui Dai, Bilin Xia, Mengyang Wang, Mingxi Huang, Lei Chen, Yan Huang, Tiansheng Chen*. Japanese medaka (Oryzias latipes) Nectin4 plays an important role against red spotted grouper nervous necrosis virus infection. Fish and Shellfish Immunology 150 (2024) 109650;

7. Wen Li, Zhi Wang, Jingjie Liang, Bilin Xia, Ruoxue Chen, Tiansheng Chen*. Role of Medaka (Oryzias latipes) Foxo3 in Resistance to Nervous Necrosis Virus Infection. Animals 2024, 14, 1587. https://doi.org/10.3390/ani14111587

8. Qian Wang a, c , Jiajie Deng d , Yuewen Jiang c , Zhi Wang c , Bilin Xia c , Tiansheng Chen b , c , *. A medaka gonad-specific lncRNA may act as pri-miR-202 to regulate testicular endocrine homeostasis and spermatogenesis. Theriogenology. 214 (2024) 273–285; https://doi.org/10.1016/j.theriogenology.2023.10.020

9. Qihua Pan, Ke Lu, Junzhi Luo, Yuewen Jiang, Bilin Xia, Lei Chen,·Mengyang Wang, Ronggui Dai, Tiansheng Chen*. Japanese medaka Olpax6.1 mutant as a potential model for spondylo‑ocular syndrome. Functional & Integrative Genomics (2023) 23:168:1-13: doi.org/10.1007/s10142-023-01090-4

10. Qihua Pan, Junzhi Luo, Yuewen Jiang, Zhi Wang, Ke Lu, Tiansheng Chen*. Medaka (Oryzias latipes) Olpax6.2 acquires maternal inheritance and germ cells expression, but functionally degenerate in the eye. Gene 872 (2023) 147439: https://doi.org/10.1016/j.gene.2023.147439

11. Qihua PAN, Junzhi LUO, Yuewen JIANG, Zhi WANG, Ke Lu, Tiansheng CHEN*. Efficient gene editing in a medaka (Oryzias latipes) cell line and embryos by SpCas9/ tRNA-gRNA. Journal of Zhejiang University SCIENCE B. 2022，23（1）：74-83. doi=10.1631/jzus.B2100343

12. Yizhou Wang，Ting Xue，Qian Wang，Bilin Xia，Qihua Pan，Tiansheng Chen*. Virus susceptibility of a new cell line derived from the fin of black carp Mylopharyngodon piceus. J Fish Biol. 2019;1–9. https://doi.org/10.1111/jfb.14215

13. Xueshu Zhang, Xiaoyan Xu, Yubang Shen, Yuan Fang, Jiahua Zhang, Yulin Bai, Shuting Gu, Rongquan Wang, Tiansheng Chen*, JIali Li*. Myeloid differentiation factor 88 (Myd88) is involved in the innate immunity of black carp (Mylopharyngodon piceus) defense against pathogen infection Author links open overlay panel. Fish Shellfish Immunol. 2019; 94:220-229. doi: 10.1016/j.fsi.2019.09.011. Epub 2019 Sep 5.

14. Fangfang Bian, Xuefen Yang, Zhijie Ou, Junzhi Luo, Bozhen Tan, Mingrui Yuan, Tiansheng Chen*, Ruibin Yang*. Morphological Characteristics and Comparative Transcriptome Analysis of Three Different Phenotypes of Pristella maxillaris. Front Genet. 2019 Aug 2;10:698. doi: 10.3389/fgene.2019.00698. eCollection 2019.

15. Qihua Pan, Ting Xue, Bilin Xia, Junzhi Luo, Qian Wang, Yuewen Jiang, Miao Yu, Tiansheng Chen*. Gonadal, Not Maternal, Acquisition of Duplicated pax6 Orthologs in Megalobrama Amblycephala. Int J Mol Sci. 2019, 20(7), 1710; doi.org/10.3390/ijms20071710.

16. Yu Deng, Qian Wang, Yizhou Wang, Ting Xue, Junzhi Luo, TianSheng Chen*. Establishment and application of a cell line from medaka (Oryzias latipes) muscle with higher transfection efficiency. Acta Hydrobiol Sin, 2019,43(2), 322-329，doi: 10.7541/2019.040.

17. Qian Wang, Jian Fang, Qihua Pan, Yizhou Wang, Ting Xue, Lingyu Li, Tiansheng Chen*. Efficient and Stable Delivery of Multiple Genes to Fish Cells by a Modified Recombinant Baculovirus System. Int J Mol Sci; 2018,19,3767. doi:10.3390/ijms19123767.

18. Jian Fang, TianSheng Chen*, Qihua Pan, Qian Wang. Generation of albino medaka (Oryzias latipes) by CRISPR/Cas9. JEZ Part B: Mol Dev Evol, 2018, 330 (4) :242-246. DOI:10.1002/jez.b.22808.

19. Ting Xue, Yizhou Wang, Qihua Pan, Qian Wang, Junfa Yuan, Tiansheng Chen*. Establishment of a Cell Line from the Kidney of Black Carp and Its Susceptibility to Spring Viremia of Carp Virus. J Fish Dis, 2018;41(2):365-374. doi: 10.1111/jfd.12736.

20. Miao Yu, Ting Xue, Tiansheng Chen*, Jian Fang, Qihua Pan,Yu Deng, Lingyu Li, Kai Chen, Yizhou Wang. Maternal inheritance of Nanog ortholog in blunt-snout bream, JEZ Part B: Mol Dev Evol, 2017 Dec;328(8):749-759. doi: 10.1002/jez.b.22760.

21. Tiansheng Chen*, Benzion Cavari,Manfred Schartl, Yunhan Hong*. Identification and Expression of Conserved and Novel RNA Variants of Medaka pax6b Gene. JEZ Part B: Mol Dev Evol, 2017, 328(5): 412-422. doi: 10.1002/jez.b.22742.

22. Ting Xue, Miao Yu, Qihua Pan, Yizhou Wan, Jian Fang, Lingyu Li,Yu Deng,Kai Chen,Qian Wang, Tiansheng Chen*. Black carp vasa identifies embryonic and gonadal germ cells. Dev Genes Evol, 2017, 227(4): 231-243. doi: 10.1007/s00427-017-0583-6.

六、获奖情况

2022年厦门市引进高层次人才“双百计划”高层次创新人才

2020年福建省闽江学者特聘教授

2014年湖北省楚天学者主讲教授

七、联系方式

通讯地址：福建省厦门市集美区印斗路43号集美大学水产学院

邮编：361021

Email：tiansheng.chen@jmu.edu.cn