副教授

一、基本情况

张东玲，女，博士，副教授，博士生导师，福建省C类人才，福建省科技特派员，兼企业技术顾问。

Emai: 342312933@qq.com

QQ: 342312933

二、研究方向

1. 鱼类遗传育种：利用多种组学方法对鱼类多种性状进行良种选育。

2. 鱼类基因组学：组装鱼类基因组，挖掘功能基因。

3. 益生菌：利用多种方法构建或分离益生菌并应用到生产。

三、近五年主持的课题

1. 国家自然科学基金面上项目，32172964，大黄鱼抗烂身病性状的遗传解析，2022.01-2025.12，资助金额：75.4万元，在研，主持。

2. 福建省种业创新与产业化工程项目，斑鳜和黑脊倒刺鲃种业创新与产业化开发，2022.08-2025.08，资助金额：90万，在研，主持。

3. 福建省自然科学基金重点项目，2022J02042, 大黄鱼抗盾纤毛虫病性状的遗传基础解析，2022.08-2025.02，资助金额：20万，在研，主持。

4. 厦门市科技局-产学研后补助项目，2024CXY0320，海洋生物活性肽抗多种副溶血弧菌活性研究与开发，2024.10-2027.10，资助金额：16万，在研，主持.

5. 企业联合横向，生产尾水处理益生菌的研发和应用，2024.04-2027.04，资助金额：50万，在研，主持。

6. 企业联合横向，大蒜E素（乙蒜素）在自然海区抗大黄鱼内脏白点病和盾纤毛虫病的应用技术研究，2024.06-2026.12，资助金额：21万，在研，主持。

7. 企业联合横向，海洋生物活性肽抗多种副溶血弧菌活性研究与开发，2023.08-2028.08，资助金额：50万，在研，主持。

8. 国家海洋水产种质资源库建设，每年资助，2019.01-至今，资助金额：5万，在研，主持。

9. 企业联合横向，大蒜E素（乙蒜素）对大黄鱼内脏白点病防治效果研究，资助金额：5万，2023.07-2025.03，在研，主持。

10. 福建省自然科学基金面上项目，2019J01692，适应无鱼粉鱼油饲料大黄鱼分子标记辅助选育的基础研究，2019.05-2022.06，资助金额：10万，结题，主持。

四、代表论著

1. Yan Chunmei, Chen meiling, Jin Jian, Liu Xiande, Wang Zhiyong, Luo Yongju, Zhang Dongling(通讯作者）*. Bacillus subtilis 2118 exhibits bactericidal activity due to an inserted fish cDNA library. Aquaculture, 2024, 593:741300.

2. Tang Xin, Xiao Zhiqun,Chen meiling, Zhu Xingcheng,Wang Zhiyong, Zhang Dongling(通讯作者）*. A prototype galectin-1 (also known as galecin-2) from large yellow croaker (Larimichthys crocea): Molecular and function study. Fish & Shellfish Immunology, 2024,145:109314.

3. Chen meiling, Xiao Zhiqun, Yan Chunmei, Tang Xin, Ming Fang, Wang Zhiyong, Zhang Dongling(通讯作者）*. Centrosomal protein of 192 kDa (Cep192) fragment possesses bactericidal and parasiticidal activities in Larimichthys crocea. International Journal of Biological Macromolecules, 2024, 254:127744.

4. Chen meiling, Lin Nengfeng, Liu Xiande, Tang Xin, Wang Zhiyong, Zhang Dongling(通讯作者）*. A novel antimicrobial peptide screened by a Bacillus subtilis expression system, derived from Larimichthys crocea Ferritin H, exerting bactericidal and parasiticidal activities. Frontiers in immunology, 2023, 1168517.

5. Tang Xin, Zhu Xingcheng, Liu Xiande, Wang Zhiyong, Zhang Dongling(通讯作者）*. A unique C-type lectin, Ladderlectin, from large yellow croaker (Larimichthys crocea) is involved in bacterial cell membrane damage. Fish & Shellfish Immunology, 2023, 136:108744.

6. Li Zeyu, Fang Ming, Tang Xin, Zhang Dongling(通讯作者）*, Wang Zhiyong*. Disentangling genetic variation for endurance and resistance to visceral white-nodules disease in large yellow croaker (Larimichthys crocea) using genome information. Aquaculture, 2023, 564:739045.

7. Tang Xin, Liu Xiande, Wang Zhiyong, Chen meiling, Zhang Dongling(通讯作者）*. Molecular Characterization, Expression, and Regulatory Signal Pathway Analysis of Inflammasome Component Apoptosis-Associated Speck-like Protein Containing a CARD Domain (ASC) in Large Yellow Croaker (Larimichthys crocea). International Journal of Molecular Sciences, 2023, 24:2175.  

8. Tang Xin, Wang Zhiyong, Jiang Dan, Chen Meiling, Zhang Dongling(通讯作者）*. Expression profile, subcellular localization of MARCH4 and transcriptome analysis of its potential regulatory signaling pathway in large yellow croaker (Larimichthys crocea). Fish & Shellfish Immunology, 2022, 52:273-282.

9. Zhang ZhenXi, Wang Zhiyong, Fang Ming, Ye Kun, Tang Xin, Zhang Dongling(通讯作者）*. Genome-wide association analysis on host resistance against the rotten body disease in a naturally infected population of large yellow croaker Larimichthys crocea. Aquaculture, 2022, 548:737615.

10. Zhang Dongling, Lv Chang Huan, Yu Da Hui, Wang Zhi Yong*. Characterization and functional analysis of a galectin-9 protein in large yellow croaker Larimichthys crocea. Fish & Shellfish Immunology, 2016, 52:167-178.

11. Lv Chang Huan#, Zhang Dongling#（共同第一作者）, Wang Zhi Yong*. A novel C-type lectin, Nattectin-like protein, with a wide range of bacterial agglutination activity in large yellow croaker Larimichthys crocea, Fish and Shellfish Immunology, 2016, 50:231-241.

12. Zhang Dongling, Da Hui Yu, Jian Chen, Zhi Yong Wang*. Co-expression and interaction suggest TBK1 can be regulated by Nrdp1 in response to immune stimulation in large yellow croaker Larimichthys crocea, Fish and Shellfish Immunology, 2015, 46:745- 752.

13. Zhang Dongling, Da Hui Yu, Jian Chen, Zhi Yong Wang*. Characterization and expression analysis of BCA2 gene in large yellow croaker, Larimichthys crocea. Fish and Shellfish Immunology, 2015, 46:543-549.

14. Zhang Dongling, Fang Han, Da Hui Yu, Shi Jun Xiao, Ming Yun Li, Jian Chen, Zhi Yong Wang*.Characterization of E3 ubiquitin ligase neuregulin receptor degradation protein-1 (Nrdp1) in the large yellow croaker (Larimichthys crocea) and its immune responses to Cryptocaryon irritans. Gene, 2015, 556:98-105.

15. Zhang Dongling, Yu Da Hui, Chen Jian, Wang Zhi Yong*. Co-expression of march5b and tlr7 in large yellow croaker Larimichthys crocea in response to Cryptocaryon irritans infection, Journal of Fish Biology, 2015, 87:360-70.

16. XuHao#, Zhang Dongling#（共同第一作者）, Yu Da Hui, Lv Chang Huan, Luo Hui Yu, Wang Zhi Yong*. Molecular cloning and expression analysis of scd1 gene from large yellow croaker Larimichthys crocea under cold stress, Gene, 2015, 568:100-108.

17. Zhang Dongling, Yu Da Hui, LuoHui Yu, Wang Zhi Yong*. WD Repeat-containing Protein 73, A Novel Gene Correlated with Gonad Development in Large Yellow Croaker, Larimichthys crocea. Journal of the World Aquaculture Society. 2016, 47:268-276.

18. Zhang Dongling，Rui Zhang Guan*, Wen Shu Huang, Jing Xiong. Isolation and characterization of a novel antibacterial peptide derived from hemoglobin alpha in the liver of Japanese eel, Anguilla japonica. Fish & Shellfish Immunology, 2013, 35: 625-631.

19. 张东玲，唐欣，王志勇*.大黄鱼UBXN1基因鉴定及其过表达后的转录组分析. 水产学报，2024, 4(48):192-201.

20. 游淞元,杨乐, 曾庆民, 张静, 黄良敏，张东玲*(通讯作者），刘贤德*. 长毛对虾(Penaeus penicillatus)SNP标记开发及亲子鉴定技术研究. 海洋与湖沼，2023. 7（54）：1165-1170.

21. 张东玲,徐浩,张震西,王志勇.大黄鱼cGPDH和mGPDH基因克隆及低温胁迫下的表达差异分析.中国水产科学,2021,28(03):253-264.

22. 蔡晓芳，张晓林，周建频，张东玲*(通讯作者），刘贤徳. 大黄鱼生态冰温保活技术的初步研究. 渔业现代化，2019，46(4):69-72.

23. 张东玲，陈健，王志勇*. 鱼类特有的MARCH5A在刺激隐核虫感染下的表达分析. 水产学报. 2016，40(3):289-298.

24. 张东玲，关瑞章*，黄文树，熊静. pH和色谱柱对日本鳗鲡肝脏抗菌肽/ 蛋白分离纯化效果的影响及抗菌活性检测. 水产学报，2013，37(4)：614-621.

25. 张东玲，关瑞章*，黄文树，熊静. 血红蛋白源抗菌片段的研究进展. 水生生物学报，2013，37(5)：936-947.

26. 张东玲. 日本鳗鲡I型Cathelicidin基因的克隆与原核表达. 生物技术通报，2015，31(7): 124-131.

27. 张东玲，关瑞章*. 鱼类Cathelicidin抗菌肽的研究进展. 集美大学学报，2013，18(6):413-419.

28. 张东玲，宋振荣. “问题式教学法”在组织胚胎学教学中的应用体会. 黑龙江畜牧兽医，2012, 5(2): 40-41.

29. 张波,姜丹,张东玲,王志勇,方铭.大黄鱼生长速率差异个体肌肉组织的转录组比较分析.水产学报，2023,47(03):87-100.

30. 罗辉玉，张东玲，叶坤，王志勇. 大黄鱼LcDCAF17基因的克隆与表达分析.集美大学学报(自然科学版)，2017,22(01):1-9.

31. 陈健，张东玲，叶坤，王志勇.大黄鱼在感染刺激隐核虫后MHC IIB基因的表达.安徽农业科学，2015，43(07):143-146.

32. 徐浩,张东玲,陈庆凯,叶坤,王志勇.低温下饥饿胁迫对大黄鱼血清生化指标的影响. 生物技术通报， 2015，31(6): 124-131.

33. Han Fang, Zhang Y, Zhang D, et al. The Rab5A gene of marine fish, large yellow croaker (Larimichthys crocea), and its response to the infection of Cryptocaryon irritans. Fish Shellfish Immunology.2016, 54:364-373.

34. Wang XL, Song Q, Wang ZY, Xie YJ, Zhang DL, et al.Characterizations of intracellular copper/zinc superoxide dismutase from yellow drum (Nibea albiflora, Richardson 1846) and its gene expressions under the ammonia/nitrite stress. Aquatic Toxicology, 2019, 214: 105254.

35. Han F, Li WB, Liu XD, Zhang DL, et al. Rac1 GTPase is a critical factor in phagocytosis in the large yellow croaker Larimichthys crocea by interacting with tropomyosin. Fish & Shellfish Immunology, 2019, 91:148-158.

36. Zhang Wenjing , Liu Guijia, Gu Linlin, Ye Kun, Zhang Dongling, et al, Gene mapping of resistance to red head disease with Pool-seq in the yellow drum, Aquaculture, 2022, 552:737923.

37. Zhu Kecheng, Zhang Dongling, et al. The complete mitochondrial genome of the hybrid grouper (♀) × Epinephelus lanceolatus (♂). Mitochondrial DNA, 2016,27:1968-1969.

38. Zhu Kecheng, Huang Guiju, Zhang Dongling, et al. The complete nucleotide sequence of Malabar grouper (Epinephelus malabaricus) mitochondrial genome. Mitochondrial DNA, 2016, 27:2087-2088.

39. Zhou Meng, Yuan Yingbo, Zhang Yongjie, Zhang Wenjing, Zhou Ruitao, Jiaojun Ji, Wu Hongshan, Zhao Yaning, Zhang Dongling, et al. The study of the genomic selection of white gill disease resistance in large yellow croaker (Larimichthys crocea). Aquaculture, 2023, 574,15,739682.

40. Fan Sigang, Zhang Dongling, et al. Characterization of the bay scallop (Argopecten irradians) transcriptome and identification of growth-related genes. Marine Genomics.2015, 24:225-227.

五、专利

1. 张东玲，吕常欢，王志勇. 大黄鱼C凝集素Nattectin基因及其重组蛋白和应用，2018.5，201510489020.4，已转让.

2. 张东玲，李杨，叶小军，王茂元，黄洪贵，王志勇，赖铭勇.一种鉴别斑鳜遗传性别的特异性分子标记及其应用，申请号：202411275853.6.

3. 张东玲，陈美玲，王志勇. 大黄鱼铁蛋白重链抗菌抗虫片段LcFet-H51及其应用，申请号：202310304433.5.

4. 张东玲，陈美玲，王志勇. 一种鱼源阴离子抗菌肽Lc149及其应用，专利号：202310304952.1.

5. 张东玲，陈美玲，王志勇. 大 黄 鱼 中 心 体 蛋 白 1 9 2 抗 菌 抗 虫 片 段LcCep192-52及应用, 申请号： 202310304794.X.

6. 宋凯，张春晓，王玲，张东玲. 一种石斑鱼保肝型中草药饲料添加剂及其制备方法与应用、石斑鱼饲料. 2019.08，ZL201810305390.1, 排名第4.