副教授

一、个人基本情况

马瑞娟，女，博士，副教授，硕士生导师，入选福建省级高层次人才C类、厦门市高层次留学人员。主要研究方向为微藻生物技术及新型水产饲料原料开发。主持国家级、省部级等多项科研项目，在国内外学术期刊发表论文30余篇。

二、教育经历

2015.11-2017.11：澳大利亚昆士兰大学，博士联培

2014.9-2018.6：厦门大学，博士

2010.9-2013.7：国家海洋局第三海洋研究所，硕士

2006.9-2010.6：中国海洋大学，学士

三、科研与学术工作经历

2024.1-至今：集美大学，副教授、硕士生导师

2018.8-2024.1：福州大学，助理研究员、副研究员、硕士生导师

2013.8-2014.8：国家海洋局第三海洋研究所，科研助理

四、科研项目

1. 国家自然科学基金青年项目，氮饥饿下雨生红球藻PⅡ蛋白在虾青素合成中的调控机制研究，2023-2025，主持

2. 福建省自然科学基金优青项目，小球藻类胡萝卜素合成限速酶PSY的翻译后调控机制，2024-2027，主持

3. 福建省自然科学基金青创项目，PⅡ蛋白调控雨生红球藻碳氮代谢网络的分子机制研究，2021-2024，主持

4. 集美大学科研启动项目，非粮型水产饲料原料开发的关键技术，2024-2026，主持

5. 横向项目，低值海鱼综合利用关键技术研发及产业化，2021-2024，主持

6. 福建省教育厅中青年教师教育科研项目，雨生红球藻高产虾青素的关键技术研究，2020-2023，主持

7. 福州大学贵重仪器设备开放测试基金，产虾青素微藻响应氮饥饿的代谢调控机制研究，2022，主持

8. 福建省科技特派员经费，2019，主持

9. 福州市科技特派员经费，2019，主持

10. 国家自然科学基金面上项目，米氏凯伦藻对低渗透压和不同类型氮源的分子响应机制研究，2020-2023，参与

11. 国家自然科学基金面上项目，一种依赖仿生辅酶的脱氢酶进化系统的建立和分子识别机制，2018-2021，参与

五、代表性论文

1. Xing Meng, Xi Li, Ruijuan Ma*, Wenjin Lin, Yiping Zou, Baobei Wang, Shih-Hsin Ho, Jianfeng Chen, Youping Xie*. A special lycopene ε-cyclase from Chromochloris zofingiensis ATCC 30412 with multiple catalytic functions. Algal Research, 2025, 87: 103974.

2. Ruijuan Ma^#, Xin Ma^#, Yongcui Qiao, Baobei Wang, Shih-Hsin Ho, Jianfeng Chen, Youping Xie*. Improved production of astaxanthin in heterotrophic Chromochloris zofingiensis through optimized culture conditions incorporating an efficient fed-batch strategy. Algal Research, 2025, 86: 103895.

3. Ruijuan Ma^#, Xinyi Tao^#, Baobei Wang, Shih-Hsin Ho, Jianfeng Chen, Youping Xie*. Hyper-production of astaxanthin from Haematococcus pluvialis by a highly efficient nitrogen feeding strategy accompanied with high light induction. Algal Research, 2025, 85: 103865.

4. Youping Xie, Wenjin Lin, Wen Zhang, Xing Meng, Ruijuan Ma*, Baobei Wang, Shih-Hsin Ho, Jianfeng Chen, Jo-Shu Chang*. Chlorophyll-deficient triggers heterotrophic lutein-directed biosynthesis in a novel mutant strain of Chlorella sorokiniana (Chlorophyta): Process characterization and underlying mechanism. Aquaculture, 2025, 598: 741998.

5. Kaiyun Huang^#, Xinyu Liu^#, Ruijuan Ma*, Baobei Wang, Shih-Hsin Ho, Jianfeng Chen, Youping Xie*. Effects of substituting fish meal with Chlorella meal on growth performance, whole-body composition, pigmentation, and physiological health of marbled eel (Anguilla marmorata). Algal Research, 2024, 80: 103523.

6. Hong Fang, Junjie Liu, Ruijuan Ma*, Yiping Zou, Shih-Hsin Ho, Jianfeng Chen, Youping Xie*. Functional characterization of lycopene β- and ε-Cyclases from a lutein-enriched green microalga Chlorella sorokiniana FZU60. Marine Drugs, 2023, 21, 418.

7. Ruijuan Ma^#, Zhen Zhang^#, Hong Fang, Xinyu Liu, Shih-Hsin Ho, Youping Xie*, Jianfeng Chen*. Unveiling the underlying molecular mechanisms of high lutein production efficiency in Chlorella sorokiniana FZU60 under a mixotrophy/photoautotrophy two-stage strategy by transcriptomic, physiological, and biochemical analyses. Biotechnology for Biofuels and Bioproducts, 2023, 16: 47.

8. Ruijuan Ma^#, Yuanwei You^#, Xinyu Liu, Shih-Hsin Ho, Youping Xie*, Jianfeng Chen*. Highly efficient co-production of fucoxanthin and eicosapentaenoic acid by heterotrophic cultivation of a newly isolated microalga Nitzschia sp. FZU62, Algal Research, 2023, 71: 103406.

9. Ruijuan Ma^#, Xinyi Tao^#, Elvis T. Chua^#, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Youping Xie*, Jianfeng Chen. Enhancing astaxanthin production in Haematococcus pluvialis QLD by a pH steady NaHCO₃-CO₂-C/NH₄Cl-N culture system, Algal Research, 2022, 64: 102697.

10. Hongling Ke^#, Ruijuan Ma^#, Xinyu Liu, Youping Xie*, Jianfeng Chen*, Highly effective peptide-calcium chelate prepared from aquatic products processing wastes: stickwater and oyster shells, LWT-Food Science and Technology, 2022, 168: 113947.

11. Youping Xie^#, Zhen Zhang^#, Ruijuan Ma^#, Xinyu Liu, Miao Miao, Shih-Hsin Ho, Jianfeng Chen, Yoong Kit Leong, Jo-Shu Chang*. High-cell-density heterotrophic cultivation of microalga Chlorella sorokiniana FZU60 for achieving ultra-high lutein production efficiency, Bioresource Technology, 2022, 365: 128130.

12. Ruijuan Ma^#, Zhen Zhang^#, Zhuzhen Tang, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Youping Xie*, Jianfeng Chen. Enhancement of co-production of lutein and protein in Chlorella sorokiniana FZU60 using different bioprocess operation strategies. Bioresources and Bioprocessing, 2021, 8:82.

13. Youping Xie, Jun Li, Shih-Hsin Ho, Ruijuan Ma*, Xinguo Shi, Lemian Liu, Jianfeng Chen. Pilot-scale cultivation of Chlorella sorokiniana FZU60 with a mixotrophy/photoautotrophy two-stage strategy for efficient lutein production. Bioresource Technology, 2020, 314: 123767.

14. Ruijuan Ma^#, Baobei Wang^#, Elvis T. Chua^#, Xurui Zhao, Kongyong Lu, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Youping Xie*, Yinghua Lu, Jianfeng Chen*. Comprehensive utilization of marine microalgae for enhanced co-production of multiple compounds. Marine Drugs, 2020, 18: 467.

15. Ruijuan Ma, Zhen Zhang, Shih-Hsin Ho, Chengxu Ruan, Jun Li, Youping Xie*, Xinguo Shi, Lemian Liu, Jianfeng Chen*. Two-stage bioprocess for hyper-production of lutein from microalga Chlorella sorokiniana FZU60: Effects of temperature, light intensity, and operation strategies. Algal Research, 2020, 52: 102119.

16. Ruijuan Ma, Xurui Zhao, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Youping Xie*, Jianfeng Chen*, Yinghua Lu. Co-production of lutein and fatty acid in microalga Chlamydomonas sp. JSC4 in response to different temperatures with gene expression profiles. Algal Research, 2020, 47: 101821.

17. Kongyong Lu^#, Xurui Zhao^#, Shih-Hsin Ho, Ruijuan Ma*, Youping Xie*, Jianfeng Chen. Biorefining and the functional properties of proteins from lipid and pigment extract residue of Chlorella pyrenoidosa. Marine Drugs, 2019, 17: 454.

18. Ruijuan Ma, Xurui Zhao, Youping Xie*, Shih-Hsin Ho, Jianfeng Chen*. Enhancing lutein productivity of Chlamydomonas sp. via high-intensity light exposure with corresponding carotenogenic genes expression profiles. Bioresource Technology, 2019, 275: 416-420.

19. Ruijuan Ma, Skye R. Thomas-Hall, Elvis T. Chua, Eladl Eltanahy, Michael E. Netzel, Gabriele Netzel, Yinghua Lu, Peer M. Schenk*. Blue light enhances astaxanthin biosynthesis metabolism and extraction efficiency in Haematococcus pluvialis by inducing haematocyst germination. Algal Research, 2018, 35: 212-222.

20. Ruijuan Ma, Skye R. Thomas-Hall, Elvis T. Chua, Eladl Eltanahy, Michael E. Netzel, Gabriele Netzel, Yinghua Lu, Peer M. Schenk*. LED power efficiency of biomass, fatty acid, and carotenoid production in Nannochloropsis microalgae. Bioresource Technology, 2018, 252: 118-126.

21. Ruijuan Ma, Skye R. Thomas-Hall, Elvis T. Chua, Faisal Alsenani, Eladl Eltanahy, Michael E. Netzel, Gabriele Netzel, Yinghua Lu, Peer M. Schenk*. Gene expression profiling of the astaxanthin and fatty acid pathways in Haematococcus pluvialis in response to different LED lighting conditions. Bioresource Technology, 2018, 250:591-602.

22. Ruijuan Ma, Yan Li*, Yinghua Lu*. Sequencing and characterization of novel PII signaling protein gene in microalga Haematococcus pluvialis. Marine Drugs, 2017, 15(10): 304.

六、联系方式

通讯地址：福建省厦门市集美区印斗路43号集美大学水产学院

邮编：361021

邮箱：rjma@jmu.edu.cn