教师基本信息
姓名：黄贝 集美大学，水产学院，教授
简介
集美大学水产学院教授，近年来主要围绕鱼类免疫系统对病原免疫识别的分子基础、信号转导关键途径、效应分子表达及作用机制等，开展鱼类抗病毒、细菌免疫应答的基础研究。共发表研究论文近60篇，其中SCI收录40余篇。主持了国家自然科学基金面上项目、青年基金，福建省自然科学基金杰出青年基金、面上项目以及厦门市青年创新基金等，2019年获集美大学青年拔尖人才计划资助。担任了福建省生化与分子生物学学会理事，《水生生物学报》青年编委，以及Reviews in aquaculture，Frontiers in immunology，Developmental & Comparative Immunology，Fish & shellfish immunology，Aquaculture，Gene report, Scientific reports等多家期刊审稿专家。
受教育经历（从大学本科开始，按时间倒排序）
2008年09 – 2012年06，中国科学院水生生物研究所，博士
2006年09 – 2008年06，中国科学院水生生物研究所，硕士
2001年09 – 2005年06，南昌大学，生命科学与食品工程学院，学士
研究工作经历（按时间倒排序）
2021年10 – 至今，集美大学水产学院，教授
2019年05 – 2019年08，台湾大学渔业科学研究所，访问学者
2015年10 – 2021年9月，集美大学水产学院，副教授
2012年12 – 2015年10月，集美大学水产学院，讲师
2012年06 – 2012年12，中国科学院水生生物研究所，研究助理
2005年07 – 2006年09，中国科学院水生生物研究所，研究助理
主持科研项目：
1）国家自然科学基金面上项目：“日本鳗鲡两个IRF2介导的I型IFN抗病毒免疫应答调控机制的研究”，课题号：32373163；2024-01-01至2027-12-31
2）国家自然科学基金面上项目：“日本鳗鲡两个RIG-I介导的免疫识别及对I型IFN抗病毒免疫应答调控作用的研究”，课题号：32073011；2021-01-01至2024-12-31
3）国家自然科学基金青年基金：“鱼类特有的干扰素调节因子11介导的免疫应答的机制”，课题号：31402329；2015-01-01至2017-12-31
4）福建省杰出青年基金：“IRF10对鱼类抗病毒免疫应答精细调控的分子机制”，课题号：2016J06008；2016-04-01至2019-03-31
5）福建省自然科学基金重点项目：“日本鳗鲡I型干扰素各亚型在抗疱疹病毒感染的功能及信号转导机制”，课题号：2024J02019；2024-11-01至2027-11-01
6）福建省自然科学基金面上：“日本鳗鲡两个新的I型干扰素基因的克隆表达及各干扰素抗病毒活性的比较”课题号：2020J01666；2020-11-01至2023-11-01
7）福建省自然科学基金青年基金：“鱼类特有的Toll样受体21基因的表达及功能的研究”课题号：2014J05042；2014-01-01至2017-03-01
8）厦门市青年创新基金：“日本鳗鲡IRF2a介导的免疫应答的分子机制”，课题号：3502Z20206022；2020-07-01至2023-06-30
9）集美大学青年拔尖人才计划“鳗鲡抗病毒免疫应答相关基因功能的研究” 课题号：ZR2020002；2019-01-01至2023-12-31
发表研究论文：
[1]. Jiao, Z.Y., Li, W.X., Xiang, C., Li, D.L., Huang, W.S., Huang, B., 2024. IRF11 synergizes with STAT1 and STAT2 to promote type I IFN production. Fish Shellfish Immunol. 150:109656.
[2]. Chen, S.N., Li, B., Gan, C., Wang, L.K., Li, L., Pang, A.N., Peng, X.Y., Ji, J.X., Deng., Y.H., Li, N., Sun, Y.L., Wang, S., Huang, B., Nie, P., 2023. Transcriptional regulation and signaling of type IV IFN with identification of the ISG repertoire in an amphibian model, Xenopus laevis J. Immunol. 210(11):1771-1789
[3]. Li, W.X., Zhao, G.J., Jiao Z.Y., Xiang, C., Liang, Y., Huang, W.S., Nie P., Huang, B., 2023. Nuclear import of IRF11 via the importin α/β pathway is essential for its antiviral activity. Dev. Comp. Immunol. 141:104649.
[4]. Chen, S.N., Gan Z., Hou J., Yang Y.C., Huang L., Huang, B., Wang S., Nie P., 2022. Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2. Nat. Commun. 13, 999
[5]. Li, W.X., Ling, L.L., Wang, Z.X., Liang, Y., Huang, W.S., Nie, P. *, Huang, B. *, 2021. Functional domains and amino acid residues of Japanese eel IRF1, AjIRF1, regulate its nuclear import and IFN/Mx promoter activation. Dev. Comp. Immunol. 103923.
[6]. Xiong, J., Huang, B., Xu, J.S., Huang, W.S., 2020. A Closed-Tube Loop-Mediated Isothermal Amplification Assay for the Visual Detection of Staphylococcus aureus. Appl. Biochem. Biotechnol .191, 201-211.
[7]. Qi, Z.#*, Xu, Y., Wang, X., Jiang, J., Meng, F., Zhang, Q., Huang, B. *, 2020. Structural analysis of toll-like receptor 18 from soiny mullet (Liza haematocheila): Giving insights on the ligand binding mechanism of fish specific TLRs. Fish Shellfish Immunol. 107, 490-496.
[8]. Liang, Y., Liu, H., Li, X., Huang, W., Huang, B., Xu, J., Xiong, J., Zhai, S., 2020. Molecular insight, expression profile and subcellular localization of two STAT family members, STAT1a and STAT2, from Japanese eel, Anguilla japonica. Gene 145257.
[9]. Huang, B., Li, W.X., Wang, Z.X., Liang, Y., Huang, W.S., Nie, P., 2020. Identification of a novel splice variant isoform of interferon regulatory factor 10, IRF10, in orange spotted grouper Epinephelus coioides. Fish Shellfish Immunol. 97, 637-647.
[10]. Gan, Z., Chen, S.N., Huang, B., Zou, J., Nie, P., 2020. Fish type I and type II interferons: composition, receptor usage, production and function. Rev. Aquac. 12, 773-804.
[11]. Li, L., Chen, S.N., Laghari, Z.A., Huang, B., Huo, H. J., Li, N., Nie, P., 2019. Receptor complex and signalling pathway of the two type II IFNs, IFN-γ and IFN-γrel in mandarin fish or the so-called Chinese perch Siniperca chuatsi. Dev. Comp. Immunol. 7:98-112.
[12]. Xiong, J., Huang, B., Guo, S.L., Xu, J.S., Huang, W., 2019. A novel multiplex PCR assay for rapid detection of virulent Aeromonas in cultured eels. J. Appl. Microbiol. 127, 418-428.
[13]. Huang, B., Wang, Z.X., Zhang, C., Zhai, S.W., Han, Y.S., Huang, W.S., Nie, P., 2019. Identification of a novel RIG-I isoform and its truncating variant in Japanese eel, Anguilla japonica. Fish Shellfish Immunol. 94, 373-380.
[14]. Huang, B., Wang, Z.X. , Liang, Y., Zhai, S.W., Huang, W.S., Nie, P., 2019. Identification of four type I IFNs from Japanese eel with differential expression properties and Mx promoter inducibility. Dev. Comp. Immunol. 91, 62-71.
[15]. Laghari, Z.A., Li, L., Chen, S.N., Huo, H.J., Huang, B., Zhou, Y., Nie, P., 2018. Composition and transcription of all interferon regulatory factors (IRFs), IRF111 in a perciform fish, the mandarin fish, Siniperca chuatsi. Dev. Comp. Immunol. 81, 127-140.
[16]. Laghari, Z.A., Chen, S.N., Li, L., Huang, B., Gan, Z., Zhou, Y., Huo, H.J., Hou, J., Nie, P., 2018. Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi. Dev. Comp. Immunol. 84, 94-108.
[17]. Huang, W.S., Wang, Z.X., Liang, Y., Nie, P., Huang, B., 2018. Characterization of MyD88 in Japanese eel, Anguilla japonica. Fish Shellfish Immunol. 81, 374-382.
[18]. Gan, Z., Yang, Y.C., Chen, S.N., Hou, J., Laghari, Z.A., Huang, B., Li, N., Nie, P., 2018. Unique composition of intronless and intron-containing type I IFNs in the Tibetan frog Nanorana parkeri provides new evidence to support independent retroposition hypothesis for type I IFN genes in Amphibians. J. Immunol. 201, 3329-3342.
[19]. Zhang, X.L., Li, N., Qin, T., Huang, B., Nie, P., 2017. Involvement of two glycoside hydrolase family 19 members in colony morphotype and virulence in Flavobacterium columnare. J. Ocean. Limnol. 35, 1511-1523.
[20]. Zhang, Q., Han, P., Huang, B., Wang, Z., Qiao, G., Wang, P., Qi, Z., 2017. Molecular cloning, characterization, and expression analysis of Cathepsin A in the Chinese giant salamander Andrias davidianus. J. Aquat. Anim. Health 29, 199-207.
[21]. Ruan, B.Y., Chen, S.N., Hou, J., Huang, B., Laghari, Z.A., Li, L., Nie, P., 2017. Two type II IFN members, IFN-gamma and IFN-gamma related (rel), regulate differentially IRF1 and IRF11 in zebrafish. Fish Shellfish Immunol. 65, 103-110.
[22]. Huang, W.S., Zhu, M.H., Chen, S., Wang, Z.X., Liang, Y., Huang, B., Nie, P., 2017. Molecular cloning and expression analysis of a fish specific interferon regulatory factor, IRF11, in orange spotted grouper, Epinephelus coioides. Fish Shellfish Immunol. 60, 368-379.
[23]. Gan, Z., Chen, S.N., Huang, B., Hou, J., Nie, P., 2017. Intronless and intron-containing type I IFN genes coexist in amphibian Xenopus tropicalis: Insights into the origin and evolution of type I IFNs in vertebrates. Dev. Comp. Immunol. 67, 166-176.
[24]. Luo, Z., Liu, Z.X., Fu, J.P., Zhang, Q.S., Huang, B., Nie, P., 2016. Immunogenicity and protective role of antigenic regions from five outer membrane proteins of Flavobacterium columnare in grass carp Ctenopharyngodon idella. J. Ocean. Limnol. 34, 1247-1257.
[25]. Huang, W.S., Duan, L.P., Huang, B., Wang, K.J., Zhang, C.L., Jia, Q.Q., Nie, P., Wang, T., 2016. Macrophage migration inhibitory factor (MIF) family in arthropods: Cloning and expression analysis of two MIF and one D-dopachrome tautomerase (DDT) homologues in mud crabs, Scylla paramamosain. Fish Shellfish Immunol. 50, 142-149.
[26]. Chen, S.N., Zhang, X.W., Li, L., Ruan, B.Y., Huang, B., Huang, W.S., Zou, P.F., Fu, J.P., Zhao, L.J., Li, N., Nie, P., 2016. Evolution of IFN-lambda in tetrapod vertebrates and its functional characterization in green anole lizard (Anolis carolinensis). Dev. Comp. Immunol. 61, 208-224.
[27]. Wu, N., Zhang, X.Y., Huang, B., Zhang, N., Zhang, X.J., Guo, X., Chen, X.L., Zhang, Y., Wu, H., Li, S., Li, A.H., Zhang, Y.A., 2015. Investigating the potential immune role of fish NCAMs: Molecular cloning and expression analysis in mandarin fish. Fish Shellfish Immunol. 46, 765-777.
[28]. Li, N., Qin, T., Zhang, X.L., Huang, B., Liu, Z.X., Xie, H.X., Zhang, J., McBride, M.J., Nie, P., 2015. Gene deletion strategy to examine the involvement of the two chondroitin lyases in Flavobacterium columnare virulence. Appl. Environ. Microbiol. 81, 7394-7402.
[29]. Jiang, X., Qin, Y.X., Lin, G.F., Huang, L., Huang, B., Huang, W.S., Yan, Q.P., 2015. FlgN plays important roles in the adhesion of Aeromonas hydrophila to host mucus. Genet. Mol. Res. 14, 6376-6386.
[30]. Huang, W.S., Duan, L.P., Huang, B., Zhou, L.H., Liang, Y., Tu, C.L., Zhang, F.F., Nie, P., Wang, T., 2015. Identification of three IFN-gamma inducible lysosomal thiol reductase (GILT)-like genes in mud crab Scylla paramamosain with distinct gene organizations and patterns of expression. Gene 570, 78-88.
[31]. Huang, L., Qin, Y., Yan, Q., Lin, G., Huang, L., Huang, B., Huang, W., 2015. MinD plays an important role in Aeromonas hydrophila adherence to Anguilla japonica mucus. Gene 565, 275-281.
[32]. Huang, B., Jia, Q.Q. Liang, Y., Huang, W.S., Nie, P., 2015. Interferon regulatory factor 10 (IRF10): Cloning in orange spotted grouper, Epinephelus coioides, and evolutionary analysis in vertebrates. Fish Shellfish Immunol. 46, 669-677.
[33]. Qin, Y., Lin, G., Chen, W., Huang, B., Huang, W., Yan, Q., 2014. Flagellar motility contributes to the invasion and survival of Aeromonas hydrophila in Anguilla japonica macrophages. Fish Shellfish Immunol. 39, 273-279.
[34]. Huang, B., Huang, W.S., Nie, P., 2014. Cloning and expression analyses of interferon regulatory factor (IRF) 3 and 7 genes in European eel, Anguilla anguilla with the identification of genes involved in IFN production. Fish Shellfish Immunol. 37, 239-247.
[35]. Fu, J.P., Chen, S.N., Zou, P.F., Huang, B., Guo, Z., Zeng, L.B., Qin, Q.W., Nie, P., 2014. IFN-gamma in turtle: conservation in sequence and signalling and role in inhibiting iridovirus replication in Chinese soft-shelled turtle Pelodiscus sinensis. Dev. Comp. Immunol. 43, 87-95.
[36]. Huang, B., Huang, W.S., Nie, P., 2013. Characterization of four Mx isoforms in the European eel, Anguilla anguilla. Fish Shellfish Immunol. 35, 1048-1054.
[37]. Chen, S.N., Huang, B., Zhang, X.W., Li, Y., Zhao, L.J., Li, N., Gao, Q., Nie, P., 2013. IFN-gamma and its receptors in a reptile reveal the evolutionary conservation of type II IFNs in vertebrates. Dev. Comp. Immunol. 41, 587-596.
[38]. Chang, M.X., Zou, J., Nie, P., Huang, B., Yu, Z., Collet, B., Secombes, C.J., 2013. Intracellular interferons in fish: a unique means to combat viral infection. PLoS Pathog. 9, e1003736.
[39]. Zhang, S.H., Zhu, D.D., Chang, M.X., Zhao, Q.P., Jiao, R., Huang, B., Fu, J.P., Liu, Z.X., Nie, P., 2012. Three goose-type lysozymes in the gastropod Oncomelania hupensis: cDNA sequences and lytic activity of recombinant proteins. Dev. Comp. Immunol. 36, 241-246.
[40]. Wang, G.L., Li, J.H., Zou, P.F., Xie, H.X., Huang, B., Nie, P., Chang, M.X., 2012. Expression pattern, promoter activity and bactericidal property of beta-defensin from the mandarin fish Siniperca chuatsi. Fish Shellfish Immunol. 33, 522-531.
[41]. Li, N., Zhang, L.Q., Zhang, J., Liu, Z.X., Huang, B., Zhang, S.H., Nie, P., 2012. Type I restriction-modification system and its resistance in electroporation efficiency in Flavobacterium columnare. Vet. Microbiol. 160, 61-68.
[42]. Wei, Y.C., Pan, T.S., Chang, M.X., Huang, B., Xu, Z., Luo, T.R., Nie, P., 2011. Cloning and expression of Toll-like receptors 1 and 2 from a teleost fish, the orange-spotted grouper Epinephelus coioides. Vet. Immunol. Immunopathol .141, 173-182.
[43]. Xu, Q.Q., Chang, M.X., Xiao, F.S., Huang, B., Nie, P., 2010. The gene and virus-induced expression of IRF-5 in grass carp Ctenopharyngodon idella. Vet. Immunol. Immunopathol. 134, 269-278.
[44]. Huang, B., Qi, Z.T., Xu, Z., Nie, P., 2010. Global characterization of interferon regulatory factor (IRF) genes in vertebrates: glimpse of the diversification in evolution. BMC Immunol. 11, 22.
[45]. Xu, Z., Chang, M.X., Qi, Z.T., Huang, B., Nie, P., 2009. Immunoglobulin joining (J) chain and its expression in the Chinese soft-shelled turtle (Pelodiscus sinensis). Vet. Immunol. Immunopathol. 131, 268-272.
[46]. 日本鳗鲡心脏细胞系的建立及其在鳗鲡免疫应答研究中的应用. 周晓玲, 李东利, 黄文树, 黄贝. 水生生物报，2024 第48卷，第11期，1884-1893页
[47]. 日本鳗鲡TRAF3基因的克隆及功能研究. 凌露露, 梁英, 黄文树, 聂品, 黄贝. 水产学报，2023，第47卷，第8期，089414
[48]. 日本鳗鲡STAT3及其剪切异构体的克隆、亚细胞定位及功能分析. 李文星，郑妨，凌露露，梁英，黄文树，聂品，黄贝，水产学报，2021，第45卷，第9期，1517-1529
[49]. 日本鳗鲡巨噬细胞移动抑制因子的基因鉴定及表达分析. 武亚芳，黄文树，段明珠，李文星，熊静，梁英，黄贝，水产学报，2020，第44卷，第9期，1549-1560
[50]. 日本鳗鲡γ干扰素诱导的溶酶体巯基还原酶（GILT）基因的克隆鉴定与表达分析. 陈珊，黄贝，张芳芳，黄文树，厦门大学学报（自然科学版）2018年，第57卷，第4期，484-493页
[51]. 日本鳗鲡TLR21基因的鉴定、免疫应答与启动子分析. 李春艳，黄贝，熊静，彭喜霞，梁英，聂品，黄文树，水生生物报，2017 第41卷，第2期，296-305页
[52]. 斜带石斑鱼干扰素调节因子8基因的鉴定与表达模式分析. 贾芹芹，黄贝，熊静，段利朋，徐继松，聂品，黄文树，厦门大学学报（自然科学版）2017年，第56卷，第2期，178-187页
[53]. 日本鳗鲡IFN-γ基因的鉴定、表达模式及启动子活性分析. 彭喜霞，黄贝，段利朋，李春艳，梁英，聂品，黄文树，水生生物学报，2017，第41卷，第3期，589-602页
[54]. 日本鳗鲡的C-型和G-型溶菌酶研究. 杨勇，黄贝，黄文树，段明珠，张芳芳，聂品，水生生物学报，2017年，第41卷，第4期，807-818页
[55]. 日本鳗鲡肝脏表达抗菌肽2基因的克隆与表达. 段明珠、黄贝、梁英、张芳芳、聂品、黄文树，水生生物学报，2016，第40卷，第2期，252-260页
[56]. 拟穴青蟹两种新C-型凝集素基因的克隆与表达分析. 段利朋、黄贝、周立红、梁英、聂 品、黄文树，水生生物学报，2015，第39卷，第2期，321-330页
[57]. 斜带石斑鱼IFN-γ基因的克隆与表达分析. 黄贝、陈善楠、黄文树、聂品，中国水产科学，2013 第20卷， 第2期，269-275页
[58]. 斜带石斑鱼IgM、IgZ和IgD重链基因的克隆. 黄贝、陈善楠、徐镇、聂品，水产学报，2012 第36卷，第7期， 1000-1010页
[59]. 梭鱼白细胞介素-22原核表达及活性蛋白的制备. 王资生、齐志涛、黄贝、张启焕、仇明、邵荣，华中农业大学学报，2012，第31卷，第6期，752-775页
[60]. 非洲爪蟾BAFF及其信号通路相关基因的比较生物信息学分析. 齐志涛、张启焕、黄贝、王资生、仇明、黄金田、许伟、王爱民，生物技术，2011，第21卷，第4期
[61]. 非洲爪蟾干扰素-λ1基因的原核表达，齐志涛、高谦、张启焕、黄贝、王爱民、王资生、聂品. 水生生物学报， 2011 第35卷，第6期，1060-1063页
[62]. 非洲爪蟾短型肽聚糖识别蛋白基因的克隆与鉴定. 齐志涛、高谦、黄贝、昌鸣先、聂品，水生生物学报，2010，第34卷，第5期，922-926页
[63]. 非洲爪蟾IL-6基因的克隆及生物信息学分析. 齐志涛、张启焕、王资生、许伟、黄贝、王爱民，生物技术通报，2010，第11期，129-133页
[64]. 白氏文昌鱼FADD的克隆及功能研究. 张晶、黄贝、高谦、聂品，水生生物学报，2009，第33卷，第6期，1175-1184页
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